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Mkey [24]
3 years ago
6

Cystic fibrosis is a devastating illness that affects the lungs, pancreas, and intestines.In 1989, researchers discovered that t

he disease is caused by a mutation in a gene that produces a proteinthat channels chloride across cellular membranes. People with two copies (or alleles) of the mutated genehave a buildup of mucus in the airways, intestines, and other organs due to nonfunctioning or absent channelproteins. Suggest two ways you could intervene to treat the disease by targeting the DNA molecule and justifywhy each approach could be effective.Student answers will vary, but answers should
Biology
1 answer:
Natalka [10]3 years ago
3 0

Answer:

There is no cure for cystic fibrosis, but treatment can ease symptoms and reduce complications.

Explanation:

1). For those with cystic fibrosis who have certain gene mutations, doctors may recommend a newer medication called ivacaftor. This medication may improve lung function and weight, increases the activity of Cystic fibrosis transmembrane conductance regulator (CFTR)protein and reduce the amount of salt in sweat. It has been approved by the Food and Drug Administration for people with cystic fibrosis who are age 6 and older. The dose depends on your weight and age.

2). For people with a certain gene mutation who are age 12 and older, another drug is available that combines ivacaftor with a medication called lumacaftor. This drug is called orkambi.

The use of Orkambi may improve lung function and reduce the risk of exacerbations.

I hope you're clear on this Daxxy

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The diagnostic feature of chondrichthyes is _____.
jonny [76]
An endoskeleton of calcified cartilage
3 0
3 years ago
4) A homozygous groucho fly ( gro, bristles clumped above the eyes) is crossed with a homozygous rough fly (ro, eye abnormality)
docker41 [41]

Answer and Explanation:

  • A homozygous groucho fly ( gro, bristles clumped above the eyes) is crossed with a homozygous rough fly (ro, eye abnormality).
  • The F1 females are testcrossed, producing these offspring: groucho 518 rough 471 groucho, rough 6 wild-type 5 1000 a) What is the linkage distance between the two genes? B) Plot the genes on a map c) If the genes were unlinked and the F1 females were mated with the F1 males, what would be the offspring in the F2 generation?

1st cross:

Parental) grogro ro+ro+ x  gro+gro+ roro

F1) gro+gro ro+ro

2nd cross:

Parental)  gro+gro ro+ro   x  grogro roro

Gametes) gro+ro+                       gro ro

                gro+ro                         gro ro

                gro ro+                        gro ro

                gro ro                          gro ro

Punnet square)  

                   gro+ro+             gro+ro              gro ro+            gro ro  

gro ro    gro+gro ro+ro   gro+gro roro    grogro ro+ro    grogro roro

gro ro    gro+gro ro+ro   gro+gro roro    grogro ro+ro    grogro roro

gro ro    gro+gro ro+ro   gro+gro roro    grogro ro+ro    grogro roro

gro ro    gro+gro ro+ro   gro+gro roro    grogro ro+ro    grogro roro

F2)

0.518 grogro ro+ro (518 individuals)

0.471 gro+gro roro (471 individuals)

0.006 grogro roro (6 individuals)

0.005 gro+gro ro+ro (5 individuals)

Total number of individuals 1000

<u><em>Note</em></u>: These frequencies were calculated dividing the number of individuals belonging to each genotype by the total number of individuals in the F2.

To know if two genes are linked, we must observe the progeny distribution. <em>If individuals, whos </em><em>genes assort independently,</em><em> are test crossed, they produce a progeny with equal </em><em>phenotypic frequencies 1:1:1:1</em>. <em>If</em> we observe a <em>different distribution</em>, that is that <em>phenotypes appear in different proportions</em>, we can assume that<em> genes are linked in the double heterozygote parent</em>.  

In the exposed example we might verify which are the recombinant gametes produced by the F1 di-hybrid, and we can recognize them by looking at the phenotypes with lower frequencies in the progeny.  

By performing this cross we know that the phenotypes with lower frequencies in the progeny are groucho, rough and wild-type. So the recombinant gametes are <em>gro+ro+</em> and <em>gro ro</em>, while the parental gametes are <em>gro+ro</em> and <em>gro ro+.</em>

So, the genotype, in linked gene format, of the double heterozygote individual in the <u>F1</u> is gro+ro/gro ro+.

To calculate the recombination frequency we will make use of the next formula: P = Recombinant number / Total of individuals. The genetic distance will result from multiplying that frequency by 100 and expressing it in map units (MU). One centiMorgan (cM) equals one map unit (MU).

The map unit is the distance between the pair of genes for which one of every 100 meiotic products results in a recombinant product.

The recombination frequency is:

P = Recombinant number / Total of individuals

P = 6 + 5 / 1000

P = 11 / 1000

P = 0.011

The <u>genetic distance between genes,</u> is 0.011 x 100= 1.1 MU.

<u>Genetic Linkage Map:</u>

Parental Phenotypes)  

-----gro+------ro----              -----gro------ro+----

----- gro ------ro----               ---- gro------ ro ----

Recombinant phenotypes)

-----gro+------ro+----              -----gro------ro----

----- gro ------ ro----                -----gro------ro----

<u>If the genes were unlinked</u> and the F1 females were mated with the F1 males, the offspring in the F2 generation would have been

4/16 = 1/4 gro+gro ro+ro  

4/16 = 1/4 gro+gro roro  

4/16 = 1/4 grogro ro+ro    

4/16 = 1/4 grogro roro

Their phenotypic frequencies would be 1:1:1:1 related.                                                  

7 0
3 years ago
Why are dead or weakened viruses used instead of normal viruses to create a vaccine?
vodomira [7]
I think its because vaccines are just to help your body learn how to fight off the virus, it’s not to actually give you the virus. Hope this helped!
5 0
3 years ago
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In 1859, Darwin published his ideas in a work entitled?
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Answer:

got this

Explanation:

The book called "On the Origin of Species"

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A) similarities between arteries and capillaries
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Some arteries carry oxygenated blood just as some capillaries do.
Some veins carry deoxygenated blood just like some capillaries do.
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