They are thought to have separate paths of evolutionary development.
They developed along different evolutionary paths.
They had independent evolutionary development.
A because it is used to treat known diseases.
Caffeine will block the action of phosphodiesterase and thus the enzyme will not be activated to break down cAMP.
Caffeine has some effects which are psychological in nature. At the cellular level, caffeine blocks the action of phosphodiesteerase. Phosphodiesterase is the one that break down the cAMP inside the cell.