Answer:
A. The chromatin near cis-regulatory sequences will be more closed and there will be less transcription.
Explanation:
In the presence of histones, the cis-regulatory sequences of DNA like promoter, enhancers etc. are not exposed. The function of the histone acetyltransferases (HATS) is to cause chromosome decondensation i.e. removal of histones from the DNA so that transcription of the DNA could occur. Histone acetyltransferases (HATS) cause acetylation of lysine amino acid of the histone proteins. Acetyl group is negatively charged so the acetylation of histone proteins leads to the removal of their positive charge which ultimately leads to the decrease in the interaction between N terminal of histones and negatively charged phosphate group of the DNA molecule. As soon as histones are removed from the DNA where cis-regulatory sequences are located, the DNA becomes accessible for transcription.
But here a drug has been added which blocks the activity of histone acetyltransferases (HATS) in cancer cells. So it is quite evident that in these cells, histones will not get removed from the cis-regulatory sequences of DNA so the DNA will be more closer or tightly packed as a result of which less transcription will occur.
Answer:
observation or experience
Explanation:
Empirical method is a study that uses indirect or direct observations in order to gain some knowledge. It uses empirical evidences-information that are collected through observation or experience.
Theory that is tested by empirical method involves the use of objective, that is observed, highly controlled and replicable.
Answer:
Mitosis is a process where a single cell divides into two identical daughter cell.
EXAMPLE ----- the way the skin cells covering a child's body all multiple when they are growing.
A mature terminally differentiated (TD) cell no longer able to undergo mitosis is defined as post mitotic cells.
EXAMPLE-------- mature neurons and mature multiple cells.
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The reference point = a object used for comparison to determine if something is in motion.
An object is in motion if it changes position relative to a reference point.
You assume that the reference point is stationary, or not moving.