Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer:
the subject of the message
the sender's name
the recipient's name
the date and time when the message was received
Explanation:
Various information is displayed in the header of the message of a received message. And they are the subject of the message, which briefs what is there inside the message. And it mentions the sender's name as well as the recipient's name, and finally, the date and the time as well are stated that explains exactly when the message was being received. And all this information is shown in the header of the message.
Answer:
En el mito de Aracne hay un acto, que se desarrolla con cinco escenas.
Explanation:
En el mito de Aracne hay un solo acto, que se desarrolla con cinco escenas. En este mito, la joven Aracne es muy hábil tejiendo, tanto así se enorgullece de su talento que se compara y se considera mejor que la diosa Atenea. Esto último ofende a la divinidad, que le advierte sobre su egocentrismo, lo que lleva a que ambas mujeres participen en una competencia. Aracne demuestra ser muy hábil pero irrespetuosa, lo que hace enfadar a la diosa. Al final, la joven se da cuenta de su error y se ahorca, pero Atenea se apiada de ella y la transforma en una araña.
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Answer:</h2><h3>Reversing switch</h3><h2 /><h2>
Explanation:</h2><h3>A device on a power drill that enables a user to back out a drill bit that is stuck in the work material is called a(n) <u>Reversing switch</u>.</h3>
A power drill is a electrical component that is used to drill or fast screw tightening and it maybe cordless or with cord. So, when the power drill is used to make hole then by using reverse switch it can be back out by rotating in opposite direction.
- It is a simple switch operated electrically.
- It used to reverse the direction in which current is flowing.
- Reversing switch has four terminals.
- These terminals can be connected in such a way that when the switch is triggered then the direction or current is reversed and so the rotation of the motor of the power drill is also reversed.
<h3>I hope it will help you!</h3>
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