Genes are connected to enzymes was first suggested by Sir Archibald Garrod. Later on, Beadle and Tatum carried out genetic studies on <em>Neurospora </em>and confirmed Garrod's hypothesis.
The link between genes and enzymes was called “one gene-one enzyme hypothesis”.
But this hypothesis is not accurate and changed because some proteins are encoded by genes are not enzymes. Some genes do not encode a whole protein but a subunit of a protein. In general, one polypeptide (a chain of amino acids) encoded by one gene.
