Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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In arabidopsis, a mutation causing the b-class genes to be non-functional will result in the organ identity of the four whorls to be; Sepal, sepal, Carpel, carpel. Arabidopsis is an angiosperm, a dicot from the mustard family Brassicaceae. It is widely used as a model organism in plant biology. It offers important advantages for basic research in genetics and molecular biology.
NaCl is dissolved in water so that in a given region or volume the concentration is initially higher in one part than the other l, thus simple diffusion will occur so that there is a net difference or 0, with respect to the concentration of NaCl in a particular volume of water than another. Basically the NaCl will be distributed throughout volume of water.
