Can you type the actual question? I cant read it.
In the beginning <span>of the RNA strand as a cap, a modified guanine nucleotide is added. After this, there is a removal of those segments of the RNA strand that do not actually code for the protein. And those RNA’s segments that do code for the protein are reconnected. And forking a tail, extra adenine nucleotides are added to the end of the RNA strand. The mRNA or messenger RNA which is already completed will then leave the nucleus. This whole process is called the RNA processing. Before the RNA copy of a protein encoding can be transported out of the nucleus and translated into protein, it must be first be modified in several ways. A precursor of mRNA, pre-mRNA is the primary transcription product of a gene. </span>
A. The sequence of DNA bases of a gene changes when a gene undergoes <span>mutation
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Hope this helps!</span>
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
Learn more about cytokine brainly.com/question/14161482
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The answer is D- Tropical rain forest
