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olchik [2.2K]
3 years ago
11

In order to impact cell differentiation and proliferation, the insulin receptor substrate 1 must be phosphorylated on a ________

_ residue and directly bind to __________.
Biology
1 answer:
Olin [163]3 years ago
3 0

Answer:

on a tyrosine residue

bind to insulin

Explanation:

The insulin receptor substrate-1 (IRS1) is a signaling protein that can be phosphorylated on multiple tyrosine and serine/threonine residues. IRS1 contains several conserved domains including a pleckstrin (PH) domain and a PTB domain involved in protein phosphorylation and ligand binding. In the first place, IRS1 is phosphorylated on a tyrosine residue, and then IRS1 binds to insulin or the insulin-like growth factor-1 (IGF-1), thereby activating transduction pathways such as, for example, MAPK/ERK. Moreover, RS1 is also phosphorylated on serine residues, thereby triggering opposite effects in insulin-associated signaling.

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Hi! Your answer is below! I made it as brief as I could.

There are many definitions, meanings, and interpretations for the word "environment," which is frequently used. What is meant by the word "environment"? In common usage, the word "environment" might simply mean "nature" to some people, which refers to the natural environment and all of its non-human qualities, traits, and processes. For those individuals, the concept of the environment is frequently strongly tied to ideas of wilderness and pristine landscapes that have not been affected by human activity, or have only been minimally affected. For some others, however, the term "environment" also contains certain human components. Many individuals would consider pastoral and agricultural landscapes to be a component of the environment, while others are even more comprehensive and believe that the environment includes all features of the earth's surface, including metropolitan regions. Therefore, in common usage, the concept of the "environment" is linked to a variety of assumptions and attitudes that are frequently unsaid but may be firmly held. All of these applications, however, share a common underlying presumption: that humans and the "environment" have some sort of relationship. As a result, the environment serves as the "backdrop" to different aspects of human history, including the habitats and resources that people use, the "hinterland" that surrounds habitations, and the "wilderness" that people have not yet tamed or subjugated.

The word "environment" simply means "surroundings" (environs) in its most basic meaning, therefore any other entity that a person, object, element, or system is surrounded by is considered a part of that entity's environment. Individuals, things, components, and systems, however, seldom live in isolation in reality; rather, they frequently engage in a variety of interactions with the entities around them. Therefore, conceptualizing the "environment" without incorporating some sort of relational idea is not especially helpful. People, things, elements, and systems all have an impact on and are in turn affected by their environment. In certain instances, the networks of connections between various entities may be enormous and extremely complicated. As a result, the "environment" may be thought of as a "space" or "field" where networks of connections, interactions, and relationships between entities take place. Such a conceptualization will be recognizable to individuals who have studied ecology because ecologists are interested in both the biotic (living) and abiotic (non-living) components of environmental systems, particularly their interactions. In reality, the terms "environment" and "ecosystem," which refer to a community of interacting species and their physical surroundings, are sometimes used synonymously in ecological contexts. Since many environmental problems have resulted from the disruption or degradation of one environmental system as a result of changes made to another, whether unintentionally or on purpose, the idea of interconnectedness is crucial to environmental science and management.

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