In the play, we are presented with many variations and interpretations of mental sickness that Lady Macbeth develops, being the central one madness. However, madness would be too general and abstract to answer this question. Diving deeper in her symptoms, it becomes more and more logic (however not explicit) that she suffered from bipolar disorder, by showing the symptoms of inflated or self-esteem grandiosity. Another possibility is that she had at the same time schizophrenia developing psychosis and hearing voices.
