Symptoms usually appear 30–60 minutes after eating toxic shellfish and includenumbness and tingling of the face, lips, tongue, arms, and legs. There may beheadache, nausea, vomiting, and diarrhea.
        
             
        
        
        
Due to the definition of the central dogma, another way of putting it is that the central dogma follows the flow of information from DNA to protein.
        
             
        
        
        
When an area is malaria-free, the HbS allele frequency is between 0 and 2.02. Thus, option "A" is correct.
<h3>How, explain your answer briefly?</h3>
In the two maps that show the allele frequency of sickle haemoglobin (HbS) and malaria endemicity in Africa, it can be seen that in the regions with no malarial outbreak or malaria-free areas coincide with the grey to lighter shades of red in the heat map of the allele frequency of HbS. The colour coding in the heat map for the allele frequency tells us that the frequencies range from 0 to 2.02 in the malaria-free areas.
Hence the answer is A)When an area is malaria-free, the HbS allele frequency is between 0 and 2.02.
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The answer is (B) Edward's Syndrome, Down Syndrome, Klinefelter's Syndrome.
These syndromes are caused when there is an extra copy of chromosomes present in the cells. 
In Edward's syndrome, there is an extra copy of the chromosome 18. 
In Down's syndrome, there is an extra copy of chromosome 21.
In Klinefelter's syndrome, there is an extra copy of X chromosome.