Question

Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria occur because _____.

Answer 1

Garrod hypothesized that individuals who could not metabolize protein could not produce the enzyme in their bodies. He was the first to identify the condition as a genetic disorder. Others thought it was caused by a bacterial infection. He came to this conclusion by noticing that the disease was more common in families where marriage between relatives was common.