The best and most correct answer among the choices provided by the question is the first choice "The hormone's signal is transduced through <span>the cytoplasm of the target cell." </span>
Water-soluble hormones<span> include glycoproteins, catecholamines, and peptide </span>hormones<span> composed of polypeptides, e.g. thyroid-stimulating </span>hormone<span>, follicle-stimulating </span>hormone<span>, luteinizing </span>hormone<span> and insulin. These molecules are not lipid-</span>soluble<span> and therefore cannot diffuse through cell membranes.</span><span> </span><span> I hope my answer has come to your help. God bless and have a nice day ahead! </span>