Answer:
The nuclear receptor superfamily comprises a large group of transcription factors that play a key regulatory role in development and homeostasis of multicellular organisms. A special feature of nuclear receptors is their ability to bind to condensed chromatin templates, which makes them important initiators of gene transcription. Moreover, the ability of nuclear receptors to sequentially recruit a variety of transcription factors and coregulators to target promoters and to orchestrate the whole process of gene transcription confirms their biological significance and stimulates intensive research and a high level of scientific interest in this field. In this review, we summarise current knowledge regarding the structure and function of nuclear receptors as principal regulators of gene expression. Emphasis is given to the molecular mechanisms of nuclear receptor-mediated transcriptional activation and repression including recent progress made in this area.
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Answer:
Methionine- Serine- Histidine- Aspartate- Glycine- stop
Explanation:
Translation, which occurs in the ribosomes, is the second stage of protein synthesis where mRNA transcript is used to synthesize a peptide chain that eventually forms a protein. The mRNA sequence is read in a group of three nucleotide called CODON. Each codon specifies a particular amino acid, which is read and added to the growing peptide chain.
In this question, a DNA sequence reds 3'- TACAGGGTGCTACCCACT-5, the
mRNA sequence from this DNA during transcription will be:
AUG UCC CAC GAU GGG UGA
From this mRNA sequence, the peptide chain that will result following translation is:
Methionine- Serine- Histidine- Aspartate- Glycine- stop
