Question

Inhibitory neurotransmitters such as glycine and GABA make a postsynaptic cell harder to depolarize by allowing what?

Answer 1

Inhibitory neurotransmitters such as glycine and GABA make a postsynaptic cell harder to depolarize by allowing "an influx of Cl-".

Explanation:

The neurotransmitters which have inhibitory influence on the neuron are termed as "Inhibitory neurotransmitters". The major inhibitory neurotransmitters involve serotonin and gamma-aminobutyric acid (GABA) in the brain and brain stem (spinal cord) respectively.

GABA uptake is temperature and ion-dependent as require both $N a^{+}$ and $C l^{-}$. Even glycine transporters are also members of the large family of $N a^{+} / C l^{-}$ dependent neurotransmitter transporters. Both of them with the GABA transporters share approximately 50% sequence identity.