Smooth muscle fibers can sustain a contraction without fatigue by allowing dephosphorylated myosin to remain attached to actin in what is called the <u>Latch State</u>.
Latch State- Myosin cross-bridge creation with actin is prevented by dephosphorylating its RLCs, however dephosphorylating myosin that is already attached to actin slows down its off rate, creating the so-called "latch state." In the latch state, smooth muscle maintains tension while undergoing modest rates of ATP hydrolysis.
ATP hydrolysis- When the high-energy phosphoanhydride bonds in adenosine triphosphate are split, as occurs, for example, in muscles, chemical energy that has been stored in them is released. This process is known as ATP hydrolysis.
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This would be a recessive disease.
Father is dd
Mother is Dd (has to be because one child has the disease)
Parents cross is dd x Dd which gives rise to Dd (0.5) and dd (0.5). Each time they have a child they have a 50% chance of the child having the disease. In their case, only one of their 3 children is dd. The others though are carriers!
The anwser is........................................ True
