Haematopoietic and lymphoid malignancies are tumors that affect the blood, bone marrow and lymphatic system and all of those elements are very closely connected. Because of the connection between the circulatory and immune system, if one of the elements is affected it is very possible that the other will be affected too. Type of hematological malignancy includes:
1. Leukemias-cancers of white blood cells which usually begin in the bone marrow
2. Lymphomas-blood cancers developed from the lymphocytes
<span>3. <span>Myelomas-cancer of plasma cells (which produce antibodies).</span></span>
The DNA replication products visualized during the sanger method of DNA sequencing are observed in which nucleotides are added.
Sanger sequencing is based on the process of DNA replication. A scientist creates a copy of his DNA strand. Then observe which nucleotides have been added. This way you can see the sequence of nucleotides. A laser excites the fluorescent labels in each band and a computer detects the resulting light.
Sanger sequencing produces extension products of various lengths ending in dideoxynucleotides at the 3' ends. Extension products are separated by capillary electrophoresis or CE. Molecules are injected by an electric current into a long glass capillary filled with gel polymer. Selective incorporation of chain-terminating dideoxynucleotides by DNA polymerases during in vitro DNA replication.
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The purpose of MHC molecules is to bind and display pathogen-derived peptide fragments on the cell surface so that the relevant T lymphocytes can recognise them.
<h3>What are MHC proteins, or major histocompatibility complex proteins?</h3>
MHC, or the major histocompatibility complex, is a set of genes that produce proteins located on the cell surfaces and that aid the immune system in identifying foreign objects. In all higher vertebrates, MHC proteins are present. The complex in humans is also known as the HLA (human leukocyte antigen) system.
<h3>What exactly are MHC proteins, and why are they crucial?</h3>
The major histocompatibility complex (MHC) is a collection of genes that code for cell surface proteins that play a significant part in the immune response. MHC molecules have a major role in how they display antigens.
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Answer: Both cell types will undergo aptosis
Explanation:
cells lacking both Bax and Bak, but not cells lacking only one of these components, are completely resistant to tBID-induced cytochrome c release and apoptosis. Moreover, doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin. Thus, activation of a “multidomain” proapoptotic member, BAX or BAK, appears to be an essential gateway to mitochondrial dysfunction required for cell death in response to diverse stimuli.
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