The study of health and disease within a geographic context and from a spatial perspective is medical geography.
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More than likely mutation
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), from animals to plants and microorganisms. Genes have been transferred within the same species, across species (creating transgenic organisms) and even across kingdoms. New genes can be introduced, or endogenous genes can be enhanced, altered or knocked out.
ECM is the extracellular matrix, or the set of extracellular molecules secreted by cells with the purpose to support surrounding cells. In plants the cell wall is the ECM and in mammals ECM can be in the form of fibrils and may constitute a significant portion of the bulk of the organism and it also referred as connective tissue.