The most likely explanation for your patient's symptoms is cimetidine inhibition of warfarin metabolism.
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What is cimetidine inhibition?</h3>
- A number of cytochrome P450 (CYP) enzymes, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4, are strongly inhibited by cimetidine.
- The medication is a mild inhibitor of the CYPs it appears to primarily inhibit: CYP1A2, CYP2D6, and CYP3A4.
- In vivo and in vitro in rats and people, cimetidine inhibits hepatic cytochrome P450 (CYP).
- To block drug metabolism in hepatic microsomes in vitro, cimetidine concentrations must be 100–1000 times greater than those linked to a comparable level of inhibition in vivo.
To learn more about cimetidine, refer:
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Long term effects are that it can result in more swelling and Edema and weakness in the effected extremity
Answer:
The absence of estrogen may lead to many symptoms:
- Irregular periods
- Anovulation, and therefore, infertility
- Hot flashes
- Decreased vaginal lubrication, which can lead to painful intercourse
- Depression, because estrogen stimulates serotonin release
- Osteoporosis and bone fractures
- Weight gain
Usually the treatment for low estrogen levels is hormone replacement therapy (orally, vaginally or topically)
A phobia is an irrational fear of something that's unlikely to cause harm. The word itself comes from the Greek word phobos, which means fear or horror
Answer:
no idea about the question
