Answer:
skeletal system is a bone that we are having in all human bodies like skeletal in our head it protects our brain. like that the skeletal system defines
When water is transferred from land to atmosphere by evaporation from the soil and by transpiration plants.
Answer:
The manager
xyz mall
(area)
(city).
Sir,
Sub-regarding loss of purse
This is to bring to ur notice that I have lost my purse in ur mall. I left my purse at the shop around 4:00 pm on Saturday 8th November 2020. It was purple in color with A brand logo of GUCCI on it and has a credit card, photo ID, debit card, and some cash.
Kindly look into this and please find my purse. I will be highly obliged.
Thanking you
Yours faithfully,
(ur full name)
(your address)
(your locality)
(your city).
(date).
Answer:
Explanation:
friction between two rock surfaces grinding away minerals.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
