Because it can catch another germ or virus
The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity.
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Reasoning/ unspoken peer pressure
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Well cardiovascular, do correct me if wrong, is something to do with your lungs, and heart (oxygen). One way to make your endurance on this is to, well, push-ups, running/jogging, and etc. Anything that makes you work hard
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