Question

Cdk inhibitors inhibit the function of cyclin-dependent protein kinases. Different inhibitors display varying mechanisms of Cdk inhibition. Which of the following might a Cdk inhibitor block in order to block the Cdk function?
a. cyclin binding
b. ATP binding
c. substrate-binding
d. movement of the T loop into the active site

Answer 1

c) is the correct option

Explanation:

Inhibition of Cdk activity occurs by Cdk inhibitory protein (CIPs)

• A group of specific proteins called CIPs binds with active cyclin Cdk complex and cause their inactivation
• Activated protein retinoblastoma (p53)act as transcriptional factor and induce synthesis of Cdk inhibitory proteins p21CIPs
• p21CIPs is a Cdk inhibitory protein that binds and inhibit the activity of G1 Cdk cyclin complex as a result cell cycle arrest in G1 phase