Answer: b) Nintendo, Game Boy
In 1989, the first handheld console was released by _Nintendo_ and it was called _Game Boy_.
Answer:
A
B
D
E
Explanation:
O to include new recipients
D to include a forgotten attachment
D to respond to a request from a recipient who accidentally deleted it
O to include missing information
Answer:
Nominal
Explanation:
- So while singing the question, let's further move to the answer. So let's see here and there.
- The first option is B. S, which corrects gross sectional data, And the 2nd 1 of Nominal, C. Is correct nominal. So here are the buddha points which are given in the question.
- The first one, option B is correct cross-sectional data, And the 2nd 1, is option C. Is correct nominal.
To learn more about it, refer
to brainly.com/question/25458754
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Not 100% sure but I can Definitely say not b or c. So you’re narrowed down to A and D.
Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
