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They saw themselves in the Enlightenment tradition, had faith in science and reason and believed in progress. The desire for social change shaped the Enlightenment debate about God, and led many to reject divine authority.
The exchange that most affected the indigenous people was the one of diseases. Native Americans hadn't encounter the diseases the European brought before, so they hadn't develop immunity to them. This is the major reason of the large death of Native Americans, besides the war between them and the brutality of the Europeans.
Colored people are allowed in the same places as whites, they can vote, and they can hold the same jobs