Question

Determine the correct steps in the activation of pka, and then place them in the correct order, starting after the adenylyl cyclase reaction.

Answer 1

After the  adenylyl cyclase reaction (which  convert ATP into cyclic adenosine monophosphate-cAMP), cAMP level is directly increased. Next steps of PKA activation include:

• cAMP binding to regulatory subunits of PKA, as a result conformational change in the regulatory subunits of PKA is induced,

•  catalytic subunits are detached and unleashed by regulatory subunits and as a result activated.