Depends on where, why, and for how long it's been hurting. Usually ice or heat will help in the process of pain relief. If that doesn't help of ice or heat from 15 minute intervals for an hour, speak to a doctor.
Secondary sexual characteristics are those that emerge during the prepubescent through postpubescent phases (e.g., breasts in females and pigmented facial hair in males).
During withdrawal from a depressant like alcohol, the user is likely to experience depression. Depressants suppress the production of neurotransmitters. So, when you stops using depressants, your brain would rebound which would result to the production of excess adrenaline causing withdrawal symptoms like depression, anxiety, headaches and irritability.