Answer:
TNF-alpha is expressed as a homotrimer that exerts its activities through binding to two types of receptors: TNFR1 and TNFR2, which are transmembrane glycoproteins characterized by having an extracellular domain with 4 cysteine-rich domains (CRD 1-4) , each with 3 cysteinecysteine disulfide bonds.
Explanation:
TNF-alpha (Tumor Necrosis Factor), which has the characteristic of being a paracrine signaling ligand, is a pleiotropic cytokine that functions as a mediator of immune regulation, the inflammatory response and apoptosis in some cell types. Receptors in this family are involved, with some exceptions, in juxtacrine signaling; that is, both the ligand and the receptor are membrane proteins with extracellular domains through which signaling is established. The cellular responses promoted by TNF are initiated by its interaction with two different types of cell receptors, the type I receptor (55 kDa) and the type II receptor (75 kDa). Both types of receptors are part of the TNF receptor family, members of which include Fas antigen (apoptosis inducer, also called Apo-1 or CD95), CD27 (T-cell activation antigen), CD30 (lymphoma marker Hodgkin) and CD40 (B-cell antigen), which share the characteristic of cysteine-rich sequences in their extracellular domains. This family of cytokines generate cellular responses that include differentiation, proliferation, activation of NFκB and cell death, promoting the aggregation of receptor monomers, that is, they have a transmembrane domain that participates in the solubilization of the receptor and a domain of intracellular death that is involved in signal transduction. The binding of TNF to TNF-R1 induces a signaling cascade through its intracellular death domain, which subsequently leads to the activation of complex I (or inflammatory) of NFkB and proceeds to the transcription of anti-apoptotic genes, pro- inflammatory diseases and apoptosis complex II (caspases).
Answer:
Roundworm
Explanation:
Unsegmented kicks out the possibility of A or D. Roundworms are pointed at their ends and have distinct males and females
ATP is required for muscle contraction. Four sources of this substance are available to muscle fibers: free ATP, phosphocreatine, glycolysis and cellular respiration. A small amount of free ATP is available in the muscle for immediate use.
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Humans, as consumers, use energy by eating food and breaking it down to release Carbon dioxide and water and is denoted as option D.
<h3>What is Cellular respiration?</h3>
This is the process in which food molecules are oxidized in the presence of oxygen to release energy.
The food is broken down into simpler units and is usually accompanied with the release of Carbon dioxide and water.
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The complete statement is "According to the biological perspective, personality is primarily determined by one’s genes" This is further explained below.
<h3>What are genes?</h3>
Generally, genes are simply defined as the biological fundamental unit of heredity that resides in a certain position on a chromosome.
In conclusion, biological personality is primarily determined by one’s genes.
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