Question

Explain why chemogenetic based methods of regulating cellular signaling result in poor temporal control of biochemical pathways relative to optogenetic based methods.

Answer 1

Answer:

They use different detecting methods to assess neuronal circuits

Explanation:

Chemogenetics is a technique widely used in neuroscience research to explore signaling interactions by means of genetically modified receptors capable of interacting with small molecules. Chemogenetics was first used to determine the function of the chalcone isomerase gene by inducing mutations that altered its substrate specificity. On the other hand, optogenetics is a bioluminescence-driven genetic technique used to control genetically modified neurons that express light-gated ion channel genes. This technique is also used to monitor neuronal networks. In consequence, optogenetic and chemogenetic techniques have recently been combined in order to analyze neuronal circuits, it by analyzing the same actuator molecule.