What changes in fatty acid metabolism would result from a mutation in the muscle carnitine acyltransferase I in which the mutant
protein has lost its affinity for malonyl-CoA but not its catalytic activity? A. Fatty acid synthesis in the mitochondria and fatty acid oxidation in the cytosol could occur simultaneously.
B. Fatty acid synthesis in the cytosol and fatty acid oxidation in the mitochondria could occur simultaneously.
C. Synthesis of malonyl carnitine could only occur at high malonyl-CoA concentration.
D. Synthesis of malonyl-CoA would no longer be inhibited carnitine.
<h2>B. Fatty acid synthesis in the cytosol and fatty acid oxidation in the mitochondria could occur simultaneously.</h2>
Explanation:
Carnitine acyltransferase I, is a mitochodrial enzyme also known as Carnitine palmitoyltransferase I (CPT1).
The acyl group is transferred to carnitine by the cytoplasmic form of the enzyme by Carnitine acyltransferase I
Malonyl coA would no longer inhibit fatty acid entry into the mitochondrion and beta oxidation, so there might be a futile cycle of simultaneous fatty acid synthesis in the cytosol and fatty acid breakdown in mitochondria.
The correct answer is: 2- Hypertension, or high blood pressure
Hypertension leads to heart failure. Also, as a result of hypertension body tends to retain fluid in order to maintain adequate blood volume. A failing heart is unable to handle that extra fluid, so it is transferred out of the blood vessels and into tissues causing the swelling of extremitets or edema.
