Answer:
Direct transmission is the way something is transmitted directly, like a illness given to you by touch.
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Example 1:
I got coronavirus through direct transmission when I hugged my infected friend.
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Example 2:
When I had pink eye, I forgot to wash my hands after reaching to scratch my diseased eye, and held my sister's hand. She ended up getting pink eye too, because of the direct transmission.
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I hope this helps!
-No one
C. delivery of carbondioxided to living cells of the body.
explanation: i asked my mom and she’s a nurse
Answer:
mike tyson is the one who bit a persons ear off and that person was evander holyfield
Explanation:
have a good day
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
