A protein kinase that is specific to the amino acids serine and threonine is known as a mitogen-activated protein kinase (MAPK or MAP kinase; also known as a serine/threonine-specific protein kinase).
<h3>Mitogen-activated protein kinase :</h3>
A small number of cell surface receptors can ultimately generate a large intracellular response due to activation of kinase cascades.
In order to trigger an appropriate physiological response, such as cellular proliferation, differentiation, development, inflammatory reactions, and death in mammalian cells, MAPK pathways relay, amplify, and integrate information from a variety of stimuli.
Tyrosine phosphorylation, specifically numerous tyrosines on each RTK in the dimer, is how cross-linking triggers the tyrosine kinase activity in these RTKs. The term "cross-phosphorylation" refers to this action.
The activation of a MAPKKKK or MAPKKK by stimulation of plasma membrane receptors is the initial stage of signal transduction. The MAPKKK then phosphorylates two serine or threonine residues in the S/T-X5-S/T (X is any amino acid) motif of its activation loop, activating a downstream MAPKK.
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Answer:
In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure.
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Explanation:
Cerebral Palsy is a brain injury it occurs while the brain is developing this could be before, during, or after birth. Mutation which is a sudden heritable change in the genome of an individual can result into cerebral palsy when the child is still developing. Mutation affects the gene changing it from it normal state to an abnormal one some mutation can be beneficial but for palsy it is detrimental one affecting the growth and development of the child.
severe jaundice in the infant could also lead to cerebral palsy in an infant child
This damage affects child’s muscle control, muscle coordination, muscle tone, reflex, posture and balance.
It can also impact a child’s fine motor skills, gross motor skills, and oral motor functioning
