There is a change in amino acids sequence causes these mutations, If there is an error in the order of amino acids during the process of multiplication, there is a special enzyme to repair errors 
        
             
        
        
        
Darwins proposed theory is the survival of the fittest.
        
             
        
        
        
The answer is:
Glands,Skin,Nails,Nerves and Hair.
I hope this helps :D 
        
             
        
        
        
Answer:
A frameshift changes every codon past it. A base substitution only changes one codon.
Explanation:
DNA is comprised of nucleotides (A, C, T, G) that make up amino acids. Every three bases is called a codon and represents an amino acid. 
In a frameshift mutation, a nucleotide is either added or deleted from the sequence. This offsets the entire sequence after it because the reading frame shifts. Here's an example:
ACTGCTATCGTCATC
If another T is added in between the first and second codons, then every codon after will be changed.
ACT>T<GCTATCGTCATC
A substitution mutation is usually less severe, as it only alters one codon in the sequence. These occur when one nucleotide is replaced by another one. Here's an example:
ACTGCTATCGTCATC
Let's say the first G is replaced by a T.
ACT>T<CTATCGTCATC
As you can see, none of the other codons changed. 
Typically, a frameshift mutation is considered worse than a substitution mutation.
 
        
                    
             
        
        
        
That cell is called ribosome.