Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems.
A few hundred Europeans could over run massive native empires
Plants, animals, culture, human populations, technology, and ideas between the Americas and the Old World in the 15th and 16th centuries
Between France and England.( Britain)