Question

A DNA mutation changes the shape of the extracellular domain of transmembrane receptor protein A produced by the cell. Which of the following predictions is the most likely consequence of the mutation? (Figure)
a. The molecule that normally binds to protein AA will no longer attach, deactivating the cellular response.
b. The glucocorticoid receptor will remain associated with the accessory proteins.
c. The intracellular concentration of glycogen will increase.
d. The SRYSRY gene produces a protein that binds to specific regions of DNADNA in certain tissues, which affects the development of these tissues.

Answer 1

a) is the correct option

Explanation:

The extracellular domain of the transmembrane receptor protein acts as binding site for primary messenger molecule whereas the transmembrane domain holds the receptor within membrane and the cytosolic domain has intrinsic tyrosine kinase activity, all these helps in proper cell signaling

If because of any mutation there is change in shape of the extracellular domain then that molecule that normally binds to the receptor protein will no longer attach hence cellular response will be deactivated