Background- In patients with intracranial artery stenosis, a long-term advantage of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been proven. We studied patients with intracranial arterial stenosis who were enrolled in the Cilostazol Stroke Prevention Study for Antiplatelet Combination trial, a randomized controlled trial in high-risk Japanese patients with ischemic stroke, to compare the efficacy and safety of DAPT with cilostazol and clopidogrel or aspirin to those of SAPT with clopidogrel or aspirin. Techniques and Outcomes In patients with ischemic stroke with symptomatic or asymptomatic intracranial arterial stenosis of at least 50% in a major intracranial artery, we compared the vascular and hemorrhagic events between DAPT and SAPT.
Patients were divided into two groups: 275 were given DAPT, while 272 were given SAPT. In contrast to SAPT, which had a higher risk of serious or life-threatening bleeding, DAPT had a lower risk of ischemic stroke (hazard ratio [HR], 0.47; 95% CI, 0.23-0.95); and a composite of stroke, myocardial infarction, and vascular mortality (HR, 0.48; 95% CI, 0.26-0.91). Conclusions In patients with intracranial artery stenosis following stroke, DAPT using cilostazol was superior than SAPT using clopidogrel or aspirin for the prevention of recurrent stroke and vascular events without raising bleeding risk.
<h3>What is
stroke?</h3>
When anything prevents blood flow to a portion of the brain or when a blood artery in the brain bursts, a stroke, also known as a brain attack, happens. The brain either ages or suffers harm in both scenarios. A stroke may result in permanent brain damage, chronic disability, or even fatality.
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<u>Behavior of Jack, the manager:</u>
Jack is the manager, he does have the authority to correct Samantha but it is also his responsibility to make Samantha comfortable. He could have explained the situation to her calmly and make her understand the problem.
He failed to some extent but he could rectify the mistake by apologizing and providing Samantha a clear explanation about how she can improve her performance. If Samantha does go to the PR and reports Jack, both of them leave the problem unsolved indicating lack of proper communication.
A manager should be able to interact well with their workers and make them see the benefits for the company and their personal interests and then invest their effort into better performance.
The correct response is Feet and ankles.
<h3>What is the term for the ankles?</h3>
The region where the foot and the leg converge is known as the ankle, the talocrural region, or the jumping bone (informally). Three joints make up the ankle the subtalar joint, the inferior tibiofibular joint, and the ankle joint proper, also known as the talocrural joint.
<h3>Where is the ankle bone located?</h3>
The tibia, the larger and stronger of the two lower leg bones, makes up the inside of the ankle and is part of the real ankle joint, which is made up of three bones the outside portion of the ankle is made up of the fibula, a tiny bone in the lower leg.
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