<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
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Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
Answer:
There is an important relationship among homeostasis, defective mitochondria, and the symptoms caused by LHON.
Explanation:
There is a great relationship among homeostasis, defective mitochondria and the symptoms caused by LHON because defective mitochondria disturbs the homeostasis in the body. If mitochondria works properly, homeostasis will be maintained whereas if there is any defect occurs in the mitochondria then the whole homeostasis will be adversely affected because mitochondria is the powerhouse of the cell responsible for the production of energy for the cell. Symptoms occurs due to Leber's hereditary optic neuropathy (LHON) also effected the state of equilibrium in the body.
