Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
protista, bacteria. archaea, fungi.
Explanation:
Heterozygous refers to a pair of alleles in which one is dominant and one is recessive. As you can see, all genotypes for possible offspring in the Punnett square are heterozygous. This means the probability of the parents having a child that is heterozygous is 100 percent likely.
Answer:
<span>D. 100%
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Answer:
Light energy is harnessed in Photosystems I and II, both of which are present in the thylakoid membranes of chloroplasts. In light-independent reactions (the Calvin cycle), carbohydrate molecules are assembled from carbon dioxide using the chemical energy harvested during the light-dependent reactions.
Explanation:
Answer:
Plant-like:
presence of flagella
shows the absence of cell wall, though chloroplast may be present
Animal-like:
absence of cell wall, as well as chloroplast
Fungus-like:
feeds on decaying matter
enclosed by a membrane called a pellicle
slime mold belongs in this category
Explanation:
The protists can be classified into three groups (plant-like, animal-like, fungus-like) based on the method of nutrition, movement, and mode of reproduction.
Plant-like protists have chloroplasts and trapped sunlight to form food ad energy (photosynthesis). They also have flagella used for the movement.
Example: Algae
Animal-like protists are heterotrophs that cannot make their food. They do not have chloroplast and cell wall outside the cell membrane.
Example: Protozoa
Fungus-like protists are single-cell eukaryotes that have a protective layer outside the cell membrane called pellicle. They feed on decaying organic matter.
Example: Slime mold and water mold
