Proteostasis is mediated by chaperone proteins and protease systems, together with cellular clearance mechanisms such as autophagy and lysosomal degradation.
Chaperone proteins control assembly and inaccurate folding by binding to and stabilizing partly or completely unfolded protein polypeptides till the polypeptide chain is completely synthesized. Chaperone proteins also confirm the stability of unfolded polypeptide chains as they are being translocated into the subcellular organelles.
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I would go with the first option
Answer
Two structures located in the diencephalon are hypothalamus and epithalamus
Explanation
The diencephalon of the human brain has four main structures which are the hypothalamus, the thalamus, the epithalamus and the subthalamus. Thalamus structure is at the center of the brain which relays sensory impulses to the cerebral cortex. The hypothalamus regulates the temperature of the body while the epithalamus maintains the circadian rhythms.
the (drug and control) are the variable that you will change throught the conducted investigation.