These reactions are METABOLISM.
Answer:
There will be a progressive fall in glomerular filtration rate.
Explanation:
The glomerular filtration rate,GFR, shows how well the Kidney is functioning or working. When the Kidney is not working well, it doesn't filter the way it should.
Note that, Glomerular filtration is the process of removing wastes and excess fluid to become part of the urine, by the kidney.
Both parents must be carriers, which means they have the heterozygous gene (one uppercase letter & one lower case letter). They will still carry that mutated gene (because they have a lower case letter), and their offspring will have a 25% chance of getting a recessive disorder. The percentage is low but still possible.