Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
Learn more about receptors here:
brainly.com/question/11985070
#SPJ4
I think false because no one knows what will happen in the future and anything is possible, although the population does increase it can still decrease by high amounts aswell, anything bad could happen any time. People may not even have money to survive but it really depends on what happens and what could happen in the future, no one really knows what will happen so this statement would be false.
Anyway have a nice day :)
Cell saps are the liquid inside of a plant cell's large central vacuole, which acts as support in order for it to function. They're made up of amino acids, glucose, salts and water and plays an important role in osmosis.
Cytoplasms, on the other hand, are a jelly-like substance between the cell membrane and nuclear envelope within a eukaryotic cell. They're mostly made up of water and salt, and aid in growth and metabolism in a cell.
I believe animals that possess homologous structures probably evolved from the same ancestor. Homologous structures are similar because of common ancestry. A homologous structure is an example of an organ or bone that appears in different animals, underlining anatomical commonalities demonstrating descent from a common ancestor.
Answer:
Explanation:
I would say no because hormones usually travel long distances via blood. This question makes it seem like it is short distance and does not talk about how the secreted entity travels. So my bet is no.
