Theories are educated guests that are tested by experiments
Answer:
Rosalind's x-ray showed that the ladders of nucleotides were inside a double helix.
Watson and Crick built models with the ladders on the outside.
<span>Cells primarily recognize exposed hydrophobic patches when identifying misfolded proteins. This is very prevalent in bacteria and I would assume that similar mechanisms are used in eukaryotes. There is also a system where misfolded proteins are tagged by different glycosylation patterns, but I don't remember much about that part.</span>