Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
Answer:
the answer is c
i did this test before in 8 grade
Answer:
Explanation:
The functional unit of the kidney responsible for excretion is the nephron . ... capillaries; Arcuate vein; Arcuate artery; Afferent arteriole; Juxtaglomerular apparatus ... If urine contains albumin or blood cells , it indicates that the glomeruli have been damaged. Binding to plasma proteins will influence urinary excretion .
Answer: D) alpha: catabolism
Explanation:
Glycogen is the storage form of carbohydrates in animals. The major sites of storage are liver and muscle.
Glucagon is a polypeptide hormone, it is secreted by the alpha cells of the pancreas. Low blood glucose causes glucagon secretion. When blood glucose level falls, liver glycogen is broken and help to maintain blood glucose level.
Glucagon stimulates the enzyme glycogen phospholylase which breaks down glycogen into glucose units.
