A mitotic inhibitor chemotherapy drug would cause the DNA to break during the early stages of cell division. Mitotic inhibitors are drugs derived from natural plant sources, and work by inhibiting cell division or mitosis, where a single cell divides into two genetically identical daughter cells. They may bind to tubulin and inhibit its polemerization into microtubules.
It is caused by the atmosphere of the Earth. It is due of the scattering of light by the atmosphere. When the moon is near the horizon, the moonlight must pass through much more atmosphere than when the moon is directly overhead.