Question

Continued strenuous activity can cause lactate to accumulate in muscles. After the activity stops, the lactate is converted into pyruvate and used as an energy source. Explain how pyruvate can be used to produce ATP.

Answer 1

The Cori cycle (also known as the lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori,[1] refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is cyclically metabolized back to lactate.[2]