The correct answer is Indus.
The Yellow River was an important part of Chinese civilization.
The Tigris River was an important part of the Mesopotamia civilization, located in modern day Iraq.
The Amazon River is located in South America, and was an important part of several different civilizations.
This shows that the only correct answer can be Indus River.
The most prominent Native American leader in the original area of English settlement in Virginia was Powhattan, who was originally welcoming to the new settlers, but then ran out of patience.
Probably their amazing sculptures.