The correct answer is letter A
Answer: Colon cancer
Explanation:
All cancers, but especially colon and rectal cancers, commonly referred to as colorectal cancer (CRC), have hereditary factors that potentially increase one’s risk.
Genetic testing is determine if there is an increased risk of colon cancer. Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified by apoE genotype. The absence of an e3 apoE allele significantly increased the risk of colon cancer especially for individuals above 50years.
They form an organ
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The false statement is: (a) Transcriptional regulators usually interact with the sugar–phosphate backbone on the outside of the double helix to determine which DNA sequence to bind.
Transcriptional regulator or factor is protein with the ability to control and regulate gene expression at the transcription level by binding to DNA. Transcriptional factors have domain-DNA-binding domain which contains structural motif that recognizes DNA and it is responsible for the attachment to specific DNA sequence. It usually binds to the DNA major groove (hydrogen bonding) because it is less degenerate than that of the DNA minor groove.
Transcriptional factors also contain trans-activating domain for the binding of other proteins and signal-sensing domain for the detection of external signals.