Answer:
* Rash progression is macular, papular, vesicular, and pustular, followed by crusted scab
* Rash is "centripetal" with lesions most abundant on the face and extremities
Explanation:
Smallpox is an infectious disease caused by viruses that are known to be variola major and variola minor. It is known to be transmitted through infective droplets during close contact with infected symptomatic people.
It should be understood that the activity of the virus is to cripple the immune system.This is by attacking molecules that made the bodies to block viral replication.
In this case, Thomas, should include those characteristics that were mentioned in the answer to educate people.
it should be noted also that, there is no cure for smallpox but only vaccination to prevent infection. And the good news is that it has been totally eradicated worldwide .