The main reason is that neither side was willing to compromise on the idea of taxation. The British need revenue to pay for the French and Indian War, and the colonists were upset that they had no representation in Congress. There was little-to-no room for compromise.
When Jeffersonian Americans sought "cultural independence" they meant that they wanted the freedom and "space" to live life the way they wished, without having to conform to the norms and customs of immigrant and other groups.
I’m guessing it’ll be the last one for the answer! I tried
