Answer:
This is an unanticipated problem, which resulted in an adverse event.
Explanation:
It is important that a study drug be thoroughly evaluated before being applied to a patient, because an error can cause very harmful reactions. However, sometimes errors go unnoticed, even if the study coordinator is cautious and tries not to make any mistakes as it may harm the patient, as happened in the case shown in the question. These errors that go unnoticed refer to a situation where an unforeseen problem has resulted in an adverse event.
By slowly introducing the changes and not implementing them all at once.
<span>because they can accelerate heart rate, increase muscle tension, elevate blood pressure</span>
Frequency, Intensity, time and type