Question

What is responsible for termination of transcription in eukaryotic protein-coding genes?

Answer 1

Answer:

A polyadenylation signal or poly(A)

Explanation:

Termination. In eukaryotes, transcription is terminated differently for the all 3 different RNA polymerases. Transcription is terminated by two elements: i) a poly(A) signal and ii) a downstream terminator sequence.

In eukaryotic protein-encoding genes, the cleavage site in the RNA occurs between an upstream( the sequence before the cleavage site) AAUAAA  and a downstream GU-rich, separated by approx 40-60 nucleotides. After they both have been transcribed, a protein knows as CPSF  and another protein called CstF( in humans)  helps in termination.