Answer:
when you put chemicals in water and the water gets chemically changed?
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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I know the first two for the fill in:
1. I believe it's energy
2. Diaphragm
Multiple choice:
1. I believe it's 3, trachea
2. I think it's 3, respiration
There's quite a lot of questions, but I hope this helps :)
Answer: can i pls get brainliest
i believe its river
Explanation:
A watershed is land that contributes water to a stream, river, lake, pond, wetland or other body of water. The boundary that separates one watershed from another, causing falling rain or melting snow or spring water to flow downhill in one direction or the other, is known as a “watershed divide”.
